By Moerder D., Pamadi B.
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Summary . . . . . . . . . . . . . . . . . . . . 65 66 INTRODUCTION The identification of a novel class of mutation, referred to as dynamic mutations (Richards and Sutherland, 1992) or tandem repeat expansions (Tables 1 and 2), has revolutionized our understanding of how genetic diseases can arise in humans. Dynamic mutations arise from genetic instability of short tandem DNA repeat sequences that are generally polymorphic. Instability generally favors the tendency toward expansion, though on some occasions, contractions in repeat lengths have been observed.
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Constrained Minimization of smooth function using a genetic algoritm by Moerder D., Pamadi B.